2007 IEEE International Conference on Image Processing - San Antonio, Texas, U.S.A. - September 16-19, 2007

Technical Program

Paper Detail

Paper:MP-P6.1
Session:Biomedical Imaging I
Time:Monday, September 17, 14:30 - 17:10
Presentation: Poster
Title: RETINA LAYER SEGMENTATION AND SPATIAL ALIGNMENT OF ANTIBODY EXPRESSION LEVELS
Authors: Nhat Vu; University of California, Santa Barbara 
 Pratim Ghosh; University of California, Santa Barbara 
 B. S. Manjunath; University of California, Santa Barbara 
Abstract: The expression levels of rod opsin and glial fibrillary acidic protein (GFAP) capture important structural changes in the retina during injury and recovery. Quantitatively measuring these expression levels in confocal micrographs requires identifying the retinal layer boundaries and spatially corresponding the layers across different images. In this paper, a method to segment the retinal layers using a parametric active contour model is presented. Then spatially aligned expression levels across different images are determined by thresholding the solution to a Dirichlet boundary value problem. Our analysis provides quantitative metrics of retinal restructuring that are needed for improving retinal therapies after injury.



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